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Hi Marlene, Your description certainly sounds as if you B12 deficiency, particularly when you combine your B12 levels with your symptoms. You will see many protocols on the web-site for getting better. One thing that you need to do before you decide which one is best for you, you need to work out why your are deficient. as this may help you choose the correct protocol. Thus, do you think it is your diet (vegan or vegetarian), genetic problems (methylation associated mutations),, metformin use, hypothyroidism, atrophic gastritis, etc, etc., or is it the colitis? Colitis can be the cause or the effect. If you have colitis, you will also have other B group deficiencies, and possibly vitamin D deficiency, and in addition most oral, sublingual, nasal spray treatments will be almost ineffective.

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Hi Marlene, Here are all the supplements that I take. I still have my period, and I definitely notice a cycle as to how good or bad I feel, so keep in mind, as a woman, it doesn’t matter if you are post or pre menopausal, you are going to have a certain number of good days and a certain number of bad days each month.

Anyway, I take Natural Factors Sublingual Methylcobalamin 2 5000mcg daily Phillips Magnesium Caplets. 2-3 daily Feosol Bifera 1 caplet daily-ish Vitafusion PowerC 2 Gummies Daily Phillips Colon Health. Probiotic caps. 1 Daily Sundown Naturals inulin Fiber Prebiotic. 4 capsules daily Vitafusion. Platinum 50+. 2 Gummies Daily Nature Made Super B Complex. 1 caplet Daily Vitafusion Vitamin D. 2 gummies Daily

I avoid artificial sweeteners as best I can. I would avoid them altogether, but they put them in so many products now, even Wrigley’s gum, that I can’t eliminate them completely.

I drink unfiltered apple cider vinegar diluted in water, or take the apple cider pills about once a week. More often makes me feel better, but, you know how it is.

I haven’t tried it yet, but I probably will, try Royal Jelly. If you are severely allergic to bees, you can’t use it, and you have to only start with like 1/8 of a teaspoon a day, but it is supposed to be good for what ails ya.

I don’t exercise at all (I know, I know). I took a Tai Chi class a few years back, and it did give me a feeling of well being. Something like that, or yoga might help you.

So, try taking the things I listed for a month or two, and see how you feel. Though, I you may want to take 2 B12’s in the morning, and 2 at night. Also, wait a little while if you are going to try the Royal Jelly, or even the Vinegar. See how you feel with the vitamins first.

If you don’t notice an improvement after 2 months, have yourself checked for allergies, viruses and the like, and parasites.

I also drink only water most of the time. Soda gums up the works,and I can feel alcohol in my system for days. I do take aspirin almost daily, but I only use enteric (coated), and never take it on an empty stomach. I also try not to take acetaminophen — I find the fact that they keep lowering the dosage and telling us what not to have with it troubling (after it being sold for over 60 years, they’re just finding out about it now?)

Just one more thing, coffee was giving me heartburn, so I now take roughly 2-3 Jet-Alert tablets a day until I can kick the caffeine ( yeah, right). They don’t have the same kick as coffee, but one pill gives me quite a bit of stamina for 3-4 hours. That might help you a bit, and for nausea, get some Clove gum, Amazon sells it.

In the summer I take Zyrtec, sudafed, and sometimes for dizziness, prescription Meclizine, which is GREAT, I can even read a map while my husbands driving, and I don’t feel like I need to throw up.

I know where you’re coming from, so I hope my drug list helps.

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laurie roberts says

The numbers of moderate or severe sore throats in the first year of the trial were as follows:

We must assume that the data for the surgical groups cannot include the immediate postoperative period as one episode of sore throat (because if they did, the mean in the surgical group would have to be > 1). Therefore, the number of episodes of moderate to severe sore throat should be 1.1 (SD 0.27) in the surgery group.

Data on the number of sore throat days in the surgical and control groups are only available for 31 and 33 children respectively (72% and 69% of those enrolled) (see Paradise 1984 , Table 5). Here sore throat days immediately after surgery are included and "the number of days for each subject for each follow-up year was standardised on the basis of 365 days". Data on the mean number of sore throat days are as follows:

The number of days with sore throat postoperatively varies considerably. In the Paradise 1984 trial a mean figure of 4.9 days is reported. In the later studies there is a mean of 6.3 days with a wide range from 0 to 21 days ( Sleeveless Maxi Dress with Premium Lace and Tulle Skirt Vintage rose/gold Chi Chi London cWVBv
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). Furthermore, it is interesting to note that despite the fact that the trial included only children who were severely affected by throat infections, following enrolment in the trial many of those in the control (non-operated) group had few episodes of infection and these few were usually mild. Of the 48 children in the original control group, seven (15%) had elected to have surgery before the end of the first year and were excluded from analysis. Another six children were excluded because of loss to follow-up (n = 4) or not completing the whole 12-month period (n = 2). Of the 35 remaining children, however, 26 (74% of that group; 54% of the whole control group) had either a single episode of moderate or severe sore throat or none at all.

Of the 95 children treated with surgery (children of the randomised and non-randomised studies combined), 13 (14%) had surgery-related complications and six of them (46% of the children that suffered from surgery-related complications; 6% of the children treated with surgery) required one or more extra days in the hospital. The primary and secondary haemorrhage rates were both 2%, of which none required transfusion.

In the Paradise 2002a ; embroidered derby shoes Black Dsquared2 sX5L3J
trials, the authors present their results in a slightly different way. Data are presented for the number of episodes in the first 12 months ( Paradise 2002a ; Malone Souliers Woman Savannah Leathertrimmed Suede Sandals Navy Size 37 Malone Souliers KO02uXs
, Table 2). However, the mean number of episodes and the range is given, along with the 95% confidence interval for the mean. For the purposes of this review, the standard deviation of the mean has had to be imputed, by dividing the confidence interval by four and multiplying by the √(N-1), where N is the number of subjects in the relevant group.

The Reviewing editor and the reviewers discussed their comments before we reached this decision, and the Reviewing editor has assembled the following comments to help you prepare a revised submission.

In general all of the reviewers felt the body of work was very impressive, and brings important new information to the field. Using live imaging, genetic/physical perturbations, quantitative data analysis and modelling they explore morphogenesis of the Drosophila pupal wing and how tissue shape changes in the Drosophila wing are related to cell shapes and mechanics. It also reveals the importance of Dumpy-dependent attachment of the disk to the cuticle. The authors develop a method to extract cell-level contributions to tissue area changes and tissue shear, and demonstrate that the various drivers of tissue shape are changing with time in interesting and robust patterns. In addition, the authors develop a fairly simple continuum model for tissue shape changes that can fit all the data in WT, mutants, and ablated embryos. This work demonstrates that both external boundary conditions as well as internal force generation are necessary to generate the WT cell shape. The deformation of wing tissues in normal and dumpy mutants is decomposed into contributions from cell growth, rearrangement and mitosis. An effort is made to distinguish autonomous cell behaviours from responses to stresses that arise from hinge reshaping and pinning of the blade margins. The experiments have been done carefully and bring important new information to the field.

In their revised version of the manuscript the authors should address the following points raised by the reviewers.

1) Calling ṽ the change in the “shear” is not precise. Some people use “shear” to refer to “shear stress” instead of shear strain. Why not call it the shear strain?

2) Why is there no autonomous active pressure in Equation 3 , which is the analogue to the active shear stress in Equation 4 ?

3) Why does Equation 52 in the supplemental include a viscous contribution to the pressure (and that's what the authors say they fit), but Equation 3 includes no such term? It is not clear when the dissipative term is included and when it is not.

4) Given that several main results in this paper rely on the fact that there is a delay ( τ d ) between the cellular topological changes ( R ) and the cell elongation ( Q ), and that this delay seems to be about 4 hours, it would be extremely useful to have some discussion of what is generating that delay. Naively, I would expect that cell elongation would drive rearrangements instantaneously—changes to shape should immediately generate T1s in fairly generic geometries. I find the existence of τ d to be incredibly surprising (although the data is convincing that it exists.) So this 4 hour timescale must be something having to do with a signaling cascade specific to biological systems? Are there any candidates for this?

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